[HTML][HTML] Murine models of obesity

T Martins, C Castro-Ribeiro, S Lemos, T Ferreira… - Obesities, 2022 - mdpi.com
genetic predisposition to developing obesity, the causes of this disease are multifactorial.
Thus, the complex … The ZFR is the most used model for the study of genetic obesity traits [42,44,…

The Fat Mass‐ and Obesity‐Associated (FTO) Gene to Obesity: Lessons from Mouse Models

JY Chang, JH Park, SE Park, J Shon, YJ Park - Obesity, 2018 - Wiley Online Library
… FTO in the risk for obesity were studied by reviewing murine models. … mouse models showed
different phenotypes depending on target tissues and methods for gene manipulation. Mice

[HTML][HTML] Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency

F Al Khazal, S Kang, MN Holte, DS Choi… - The FASEB …, 2021 - ncbi.nlm.nih.gov
… ), a mitochondrial membrane‐bound enzyme complex that is involved in both the tricarboxylic
… Here, we describe a mouse model intended to reproduce hereditary PPGL through Cre‐…

[HTML][HTML] The genetics of obesity: from discovery to biology

RJF Loos, GSH Yeo - Nature Reviews Genetics, 2022 - nature.com
genetics was also used to reveal that the complex obesity phenotype of Agouti ‘lethal yellow’
mice … identified through human and animal models of extreme obesity for a role in common …

Genetics of obesity: what we have learned over decades of research

C Bouchard - Obesity, 2021 - Wiley Online Library
… Such a genetic predisposition has a complex genomic anatomy, as revealed by advances
mouse models. The emerging biology was then compared with the panel of determinants of …

The genetics of obesity

R Alonso, M Farías, V Alvarez, A Cuevas - Translational cardiometabolic …, 2016 - Elsevier
… from animal models, cellular model … , obesity is a complex disease resulting from the
interaction between hereditary and environmental factors. Genetic and molecular basis of obesity

[HTML][HTML] Obesity-associated cancers: evidence from studies in mouse models

H Lee - Cells, 2022 - mdpi.com
… of obesity from its associated abnormal manifestation is difficult and because there is a lack
of suitable preclinical animal modelsobesity-linked cancer. Therefore, suitable preclinical …

[HTML][HTML] Integration of genomic and transcriptomic data of inbred mouse models for polygenic obesity and leanness revealed “obese” and “lean” candidate alleles in …

M Šimon, Š Mikec, NM Morton, SS Atanur, S Horvat… - Gene Reports, 2024 - Elsevier
genetic mechanisms, particularly in obesity development. … obesity is a complex trait influenced
by numerous genetic and … levels, and background genetic variations that could influence …

Preclinical models for obesity research

P Barrett, JG Mercer, PJ Morgan - Disease models & …, 2016 - journals.biologists.com
… Human obesity is a complex genetic trait in which multiple genes and … ‘mouse models of
obesity’ towards the concept of ‘mouse models to understand obesity’, where the model may not …

Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome

DS Sinasac, JD Riordan, SH Spiezio… - … Journal of Obesity, 2016 - nature.com
… , environmental and gene–environment interaction effects, identify disease genes and infer
systems properties in simple and complex genetic conditions. Surveys of common inbred …